Thursday, October 10th 2019

15:00 Registrations
17:00-18:30 E-posters Discussion
18:45-19:00 Welcome Αddresses
N.M. Appelman-Dijkstra, P. Makras
19:00-20:30 SESSION 1
Chairs: N.M. Appelman-Dijkstra, P. Makras
19:00-19:45 Osteoporosis: where we have been, G. Lyritis
19:45-20:30 Osteoporosis: where are we going, S. Ferrari
20:30-21:00 SESSION 2
Chairs: E. Kataxaki, E. Kaskani
20:30-20:45 Educating physicians for osteoporosis, G. Kapetanos
20:45-21:00 Educating patients for osteoporosis, A. Kotsopoulou
21:00-21:15 Discussion – Closing
P. Makras

Friday, October 11th 2019

09:00-10:30 SESSION 3
Chairs: T.J. de Vries, E. Kassi
09:00-09:30 Molecular mechanisms of ion transport in metabolic bone diseases, B.C.J. van der Eerden
09:30-10:00 Non coding Rnas and bone metabolism, M. Yavropoulou
10:00-10:30 From mouse models to humans: the RANKL paradigm, E. Douni
10:30-10:45 Coffee Break
10:45-12:10 ORAL PRESENTATIONS
Chairs: S. Polyzos, T.J.A.G. Münker

O01 THE EFFECT OF DURATION OF VITAMIN D3 APPLICATION ON THE OSTEOGENIC DIFFERENTIATION OF HUMAN ADIPOSE STEM CELLS
Kelder C., Hogervorst J.M.A., Kleverlaan C.J., de Vries T.J., Wismeijer D., Bakker A.D.
Academic Centre for Dentistry Amsterdam (ACTA), University of Amsterdam and Vrije
Universiteit Amsterdam, The Netherlands

O02 hMSC-TERTSCAS9: A VERSATILE TOOL TO STUDY OSTEOBLAST GENE FUNCTION
van de Peppel J.1, Mies R.1, Guo Y.1, van der Eerden B.C.J.1, Kassem M.2, van der Oost J.3,
Mathijssen I.M.J.4, van Leeuwen J.P.T.M.1
1Erasmus MC, Department of Internal Medicine, Rotterdam, The Netherlands,
2Odense University Hospital, Department of Endocrinology and Metabolism, Odense,
Denmark, 3Wageningen University, Department of Microbiology, Wageningen, The Netherlands,
4Erasmus MC, Department of Plastic and Reconstructive Surgery, Rotterdam,
The Netherlands

O03 SURFACE CHARACTERISTICS OF AND CELLULAR RESPONSES TO COATED PERSONALIZED MEDICAL DEVICES
Münker T.J.A.G.1, van Diemen E.1, Zandieh Doulabi B.1, Becking A.G.2, Kleverlaan C.J.1
1Academic Centre for Dentistry Amsterdam (ACTA), Amsterdam NL,
2Amsterdam University Medical Centers (Amsterdam UMC), Amsterdam NL

O04 HOMEODOMAIN TRANSCRIPTION FACTOR MEIS1 INHIBITS OSTEOGENIC DIFFERENTIATION AND ECM MINERALIZATION IN HMSC-TERTS
Guo Y.1, Mies R.1, Kassem M.2, van Leeuwen H.1, van de Peppel J.1
1Erasmus MC, Departments of Internal Medicine, Rotterdam, The Netherlands,
2Department of Molecular Endocrinology, University of Southern Denmark and Odense
University Hospital, Denmark

O05 ENDOTHELIAL CELL PHYSIOLOGY IN A MICROFLUIDIC DEVICE AND THEIR RESPONSE TO MESENCHYMAL STROMAL CELLS IN VITRO
Zhang S.1, Tuk B.2, van Neck J.W.2, Koedam M.1, van Leeuwen J.P.T.M.1, van Steijn V.3,
van der Eerden B.C.J.1
1Department of Internal Medicine, Erasmus MC, Rotterdam, The Netherlands, 2Department
of Plastic and Reconstructive Surgery, Erasmus MC, Rotterdam, The Netherlands, 3 Department
of Chemical Engineering, TU Delft, The Netherlands

O06 OCY454 AS A NOVEL OSTEOCYTE MODEL TO STUDY PHOSPHATE HOMEOSTASIS
Ratsma D.M.A.1, Schreuders-Koedam M.1, Zillikens M.C.1, van der Eerden B.C.J.1
1Erasmus University Medical Center, Rotterdam, The Netherlands

O07 THE EFFECT OF VITAMIN D ON THE EXTRACELLULAR VESICLE COMMUNICATION IN BONE METASTASIS
Klazen J.A.Z.1, Robbesom – van den Berge I.J.1, Hartjes T.A.1, Van Royen M.E.1,
Libregts S.2, Van Wijnen A.3, Zillikens M.C.1, Van Leeuwen J.P.T.M., Van Driel M.J.J.E.1
1Erasmus Medical Center, Rotterdam, The Netherlands, 2Utrecht University, Utrecht,
The Netherlands, 3Mayo Clinic, Rochester, Minnesota, USA
12:10-13:10 Satellite Symposium A UNIVERSE OF NEW UNDERSTANDING IN FRAGILITY FRACTURES
Chair: S.E. Papapoulos
12:10-12:40 Bones in space: Microgravity and its effects, S. Johnston
12:40-13:10 Bone modeling vs remodeling in the adult skeleton: Impact on bone strength, S. Ferrari

13:40-14:10 FLS UPDATE
Chairs: E. Panagiotopoulos, C. Kosmidis
13:40-13:55 Fracture Liaison Services: the Dutch experience, N.M. Appelman-Dijkstra
13:55-14:10 Fracture Liaison Services: the Greek experience, P. Makras
14:10-16:25 SESSION 4
Chairs: M.C. Zillikens, G. Trovas
14:10-14:40 Discontinuation of osteoporosis treatment, A. Anastasilakis
14:40 -15:10 Hip fractures: the winning patient, Th. Karachalios
15:10-16:25 ORAL PRESENTATIONS
Chairs: M.C. Zillikens, G. Trovas
O08 EFFECT OF CALCIUM AND VITAMIN D SUPPLEMENTATION WITH AND WITHOUT COLLAGEN PEPTIDES ON BONE MINERAL DENSITY AND BONE TURNOVER IN POSTMENOPAUSAL WOMEN WITH OSTEOPENIA – PRELIMINARY RESULTS
Karlafti E.1, Lampropoulou-Adamidou K.1, Argyrou Ch.1, Tournis S.1, Makris K.2,
Trovas G.1, Dontas I.1, Triantafyllopoulos I.K.1
1Laboratory for Research of the Musculoskeletal System “Th. Garofalidis”, Medical School,
National and Kapodistrian University of Athens, General Hospital of Athens KAT, Greece,
2Clinical Biochemistry Department, General Hospital of Athens KAT, Greece

O09 DIETARY INTAKE OF ADVANCED GLYCATION END PRODUCTS AND BONE MINERAL DENSITY AND PREVALENT FRACTURES: THE ROTTERDAM STUDY
Chen J.1,2, Waqas K.1, Trajanoska K.1,2, Koromani F.1,2, Uitterlinden A.G.1,2,
Rivadeneira F.1,2, Zillikens M.C.1
1Department of Internal Medicine, Erasmus MC University Medical Center, Rotterdam,
The Netherlands, 2Department of Epidemiology, Erasmus MC University Medical Center,
Rotterdam, The Netherlands

O10 BONE MATERIAL STRENGTH INDEX AS MEASUERED BY IMPACT MICROINDENTATION IN VIVO IS NORMAL IN SUBJECTS WITH HIGH-ENERGY TRAUMA FRACTURES
Schoeb M., Winter E.M., Malgo F., Papapoulos S.E., Appelman-Dijkstra N.M.
Center for Bone Quality, Leiden University Medical Center, Department of Medicine,
Division of Endocrinology, Leiden, The Netherlands

O11 TERIPARATIDE TREATMENT IN 16 PATIENTS WITH PREGNANCYAND LACTATION-ASSOCIATED OSTEOPOROSIS
Lampropoulou-Adamidou K.1, Trovas G.1, Triantafyllopoulos I.K.1, Yavropoulou M.P.2,
Anastasilakis A.D.3, Anagnostis P.4, Toulis K.A.3, Makris K.5, Balanika A.6, Tournis S.1
1Laboratory for the Research of Musculoskeletal System “Th. Garofalidis”, Medical School,
National and Kapodistrian University of Athens, KAT Hospital, Greece, 21st Department of
Propaedeutic Internal Medicine, National and Kapodistrian University of Athens, School of
Medicine, Laikon General Hospital, Athens, Greece, 3Department of Endocrinology, 424 General
Military Hospital, Thessaloniki, Greece, 4Unit of Reproductive Endocrinology, First Department
of Obstetrics and Gynecology, Medical School, Aristotle University of Thessaloniki, Greece,
5Biochemistry Departement, KAT Hospital, Athens, Greece, 6Department of Computed
Tomography, Asklepeion Voulas Hospital, Athens, Greece

O12 CLUSTERING OF HIP FRACTURE PATIENTS BY BONE METABOLISM MEASUREMENTS
Papakitsou E.1, Giannikou P.2, Andreopoulos A.2, Giannakopoulos I.2, Morakis A.2,
Sarantos K.2, Sarras E.2, Skagias K.2, Tsagari A.2, Dontas I.3, Lyritis G.4
1Laiko General Hospital, Athens, 2KAT Hospital, Kifissia, 3Laboratory for the Research of
Musculoskeletal System, Kapodistrian University, Kifissia, 4Hellenic Osteoporosis Foundation,
Kifissia

O13 PREVALENCE OF VERTEBRAL FRACTURES IN OSTEOPOROTIC PATIENTS OF THE GENERAL POPULATION IN GREECE: THE VERTEBRAL INTEGRITY ASSESSMENT (VERTINAS) STUDY
Stathopoulos K.D.1, Chronopoulos E.1,2, Kaskani E.1, Drakopoulou T.3, Ibro E.3, Kosmidis C.1
1Hellenic Society for the Study of Bone Metabolism, 22nd Department of Orthopaedics, National
and Kapodistrian University of Athens, School of Medicine, Greece, 3 Butterfly Bone Health
Society, Athens, Greece

16:45-18:15 SESSION 5
Chairs: W.F. Lems, I. Yovos
16:45-17:15 Stress and skeletal health, G. Chrousos
17:15-17:45 Osteoporosis and the vasculature, S.E. Papapoulos
17:45-18:15 Extraskeletal effects of bisphosphonates, I. Reid
18:30-19:00 Satellite Lecture
Chair: K. Mavroudis
Hypophosphatasia, S. Tournis
19:00-19:30 Satellite Lecture
Chair: S.E. Papapoulos
Vitamin D: a real myth in clinical practice, A. Giustina
19:30-20:00 Satellite Lecture
Chair: G. Trovas
The osteoporosis treatment continuum and the position of anabolic therapy, M. Yavropoulou

Saturday, October 12th 2019

09:00-10:35 SESSION 6
Chairs: B.C.J. van der Eerden, E. Chronopoulos
09:00- 09:30 Molecular genetic diagnosis in early-onset osteoporosis, E. Tsourdi
09:30-10:00 Early detection, genetic background and management of atypical femoral fractures, M.C. Zillikens
10:00-10:35 ORAL PRESENTATIONS
Chairs: B.C.J. van der Eerden, E. Chronopoulos

O14 CIRCADIAN RHYTHM IS ESSENTIAL FOR BONE HEALTH
Schilperoort M.1, Bravenboer N.1,2, Kroon J.1, Lim J.1, Mletzko K.3, Busse B.3,
van Ruijven L.4, Rensen PCN.1, Kooijman S.1, Winter EM.1
1Leiden University Medical Center, Leiden, The Netherlands, 2Amsterdam University Medical
Centers, location VUMC, Amsterdam, The Netherlands, 3University Medical Center Hamburg-
Eppendorf, Hamburg, Germany, 4Academic Centre for Dentistry Amsterdam, Amsterdam,
The Netherlands

O15 SKIN AUTOFLUORESCENCE, A NONIVASIVE BIOMARKER FOR ADVANCED GLYCATION ENDPRODUCTS, IS ASSOCIATED WITH PREVALENT VERTEBRAL AND MAJOR OSTEOPOROTIC FRACTURES: THE ROTTERDAM STUDY
Waqas K.1, Chen J.1,2,Trajanoska K.1,2, Koromani F.1,2, Uitterlinden A.G.1,2, Rivadeneira F.1,2,
Zillikens M.C.1
1Department of Internal Medicine, Erasmus Medical Center, Rotterdam, The Netherlands,
2Department of Epidemiology, Erasmus Medical Center, Rotterdam, The Netherlands

O16 IDENTIFYING CAUSAL GENES FOR FAMILIES WITH HISTORY OF OSTEOPOROSIS AND/OR ATYPICAL FEMUR FRACTURES WITH EFFORT TO BUILD A COMMON WORKFLOW
Zhou W., van de Laarschot D.M., Verkerk J.M.H., Zillikens M.C.
Department of Internal Medicine, Erasmus Medical Center, Rotterdam, The Netherlands
10:45-12:45 SESSION 7
Chairs: N. Bravenboer, E. Stathopoulos
10:45-11:15 Analysis of in-vivo bone structure, adaptation and strength using high resolution peripheral quantitative CT, A. van Rietbergen
11:15-11:45 Radio-labelled analogues in the diagnosis of bone diseases, S. Chatziioannou
11:45-12:15 Bone material properties and fragility fractures, E.P. Paschalis
12:15-12:45 Implementation of microidentation in clinical practice, N.M. Appelman-Dijkstra
12:45- 13:45 Satellite Symposium OSTEOPOROSIS: A CHRONIC DISEASE REQUIRING CHRONIC TREATMENT
Chairmen: N.M. Appelman-Dijkstra, P. Makras
Long term management of osteoporosis, S.E. Papapoulos
Setting treatment targets, P. Makras
14:15-16:15 SESSION 8
Chairs: N.A.T. Hamdy, A. Mavrogenis
14:15-14:45 Hematologic malignancies and bone metabolism: the multiple myeloma paradigm, E. Terpos
14:45-15:15 Animal and cell models to study periodontitis, the most common inflammatory bone disease, T.J. de Vries
15:15-16:15 ORAL PRESENTATIONS
Chairs: N.A.T. Hamdy, A. Mavrogenis

O17 IMPACT MICROINDENTATION ASSESSES PERIOSTEAL BONE MATERIAL PROPERTIES IN HUMANS
Rokidi S.1, Bravenboer N.2, Gamsjaeger S.1, Chavassieux P.3, Klaushofer K.1, Paschalis E.1,
Papapoulos S.E.2, Appelman-Dijkstra N.M.2
1Ludwig Boltzmann Institute of Osteology at Hanusch Hospital, Vienna, Austria
2Leiden Center for Bone Quality, Leiden University Medical Center, Leiden, The Netherlands,
3INSERM UMR 1033, University of Lyon, Lyon, France

O18 BONE MATERIAL STRENGTH INDEX AS MEASURED BY IMPACT MICROINDENTATION IN VIVO IS ALTERED IN PATIENTS WITH PRIMARY HYPERPARATHYROIDISM
Schoeb M.1, Winter E.M.1, Schepers A.2, Snel M.1, Appelman-Dijkstra N.M.1
1Center for Bone Quality and Center for Endocrine Tumours, Department of Internal Medicine,
Leiden University Medical Center, Leiden, the Netherlands, 2Center for Bone Quality and Center
for Endocrine Tumours, Department of Surgery, Leiden University Medical Center, Leiden,
Τhe Netherlands

O19 MAZABRAUD’S SYNDROME IS OFTEN ASSOCIATED WITH COMPLICATIONS OF FD/MAS; A MULTICENTER INTERNATIONAL COHORT STUDY
Hagelstein-Rotman M.1,2, Boyce A.M.3, Dur N.B.J.2, Majoor B.C.J.2, Gensburger D.4,
van de Sande M.A.J.2, Dijkstra P.D.S.2, Chapurlat R.4, Appelman-Dijkstra N.M.1
1Department of Medicine: Division of Endocrinology, Centre for Bone Quality, Leiden University
Medical Center, Leiden, the Netherlands, 2Department of Orthopaedic Surgery, Centre for Bone
Quality, Leiden University Medical Center, Leiden, The Netherlands, 3Skeletal Disorders and Mineral
Homeostasis Section, National Institute of Dental and Craniofacial Research, National Institutes
of Health, Bethesda, Maryland, 4INSERM UMR 1033, University of Lyon, Hôpital Edouard Herriot,
Lyon, France

O20 GORHAM STOUT SYNDROME OF THE PARIETAL BONE: A RARE CASE WITH A CHALLENGING TREATMENT APPROACH
De Keyser C.E.1, Bos E.M.2, Zillikens M.C.1
1Department of Internal Medicine, Erasmus Medical Center, Rotterdam, The Netherlands,
2Department of Neurosurgery, Erasmus Medical Center, Rotterdam, The Netherlands

O21 SPECIALIZED SURGICAL TREATMENT OF FIBROUS DYSPLASIA
Meier M., Majoor B., Appelman-Dijkstra N., Van de Sande M.
Leiden University Medical Center, Leiden, The Netherlands
16:30-18:05 SESSION 10
Chairs: N. Papaioannou, E.M. Winter
16:30-17:00 Glucocortocoid induced Osteoporosis, W.F. Lems
17:00 -17:30 Chronic kidney disease mineral and bone disorder, N.A.T. Hamdy

17:30-18:05 ORAL PRESENTATIONS
Chairs: N. Papaioannou, E.M. Winter
O22 SERUM PHOSPHATE AND BMI IN THE ROTTERDAM STUDY: A BIDIRECTIONAL MENDELIAN RANDOMIZATION ANALYSIS
Bosman A., Campos-Obando N., Ligthart S., Voortman T., Ikram M.A., van der Eerden
B.C.J., Uitterlinden A.G., Zillikens M.C.
Erasmus University Medical Center, Rotterdam, NL

O23 CHARACTERIZATION OF THE PATHOPHYSIOLOCIAL PROCESSES OF OSTEOARTHRITIS USING RNA SEQUENCING DATA OF SUBCHONDRAL BONE
Tuerlings M.1, Coutinho De Almeida R.1, Nelissen R.G.H.H.2, Ramos Y.F.M.1, Meulenbelt I.1
1Dept. of Biomedical Data Sciences, section Molecular Epidemiology, LUMC, Leiden NL,
2Dept. of Orthopaedics, LUMC, Leiden NL

O24 IS SOLUBLE CTLA-4 RELATED TO THE ONSET OF ACUTE PHASE RESPONSE (APR) IN PATIENTS WITH INFLAMMATORY RHEUMATIC DISEASES (IRD) RECEIVING INTRAVENOUS ZOLEDRONATE (ZOL)?
Giusti A.1, Camellino D.1,2, Saverino D.2, Iervasi E.2, Girasole G.1, Bianchi G.1, Papapoulos S.E.1,3
1Rheumatology Division, Musculoskeletal System Department, Local Health Trust 3, Genoa,
Italy, 2Autoimmunology Laboratory, Department of Internal Medicine, University of Genoa, Italy,
3Center for Bone Quality, Leiden University Medical Center, Leiden, The Netherlands
18:30-19:00 Satellite Lecture
Chair: P. Makras
Daily doses vs monodose of vitamin D, G. Boutzios
19:00-20:00 E-posters Discussion
20:00 Closing of the meeting